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Science 3 October 1997:
Vol. 278. no. 5335, pp. 24 - 25
DOI: 10.1126/science.278.5335.24
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News
AIDS/HIV:
Weakened SIV Vaccine Still Kills
Jon Cohen
An AIDS advocacy group is stepping up a campaign to test "attenuated" HIV vaccines in people, but several monkey experiments suggest that achieving protection without causing disease may be difficult. The new data, which come from several labs, reveal that a vaccine made from weakened SIV--HIV's simian analog--can cause full-blown AIDS in adult monkeys.
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Immunization of Rhesus Macaques with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen Induces Broad Simian Immunodeficiency Virus (SIV)-Specific T-Cell Responses and Reduces Initial Viral Replication but Does Not Prevent Disease Progression following Challenge with Pathogenic SIVmac239.
- H. Horton, T. U. Vogel, D. K. Carter, K. Vielhuber, D. H. Fuller, T. Shipley, J. T. Fuller, K. J. Kunstman, G. Sutter, D. C. Montefiori, et al. (2002)
J. Virol.
76, 7187-7202
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- Vaccination of Macaques against Pathogenic Simian Immunodeficiency Virus with Venezuelan Equine Encephalitis Virus Replicon Particles.
- N. L. Davis, I. J. Caley, K. W. Brown, M. R. Betts, D. M. Irlbeck, K. M. McGrath, M. J. Connell, D. C. Montefiori, J. A. Frelinger, R. Swanstrom, et al. (2000)
J. Virol.
74, 371-378
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- Role of Immune Responses against the Envelope and the Core Antigens of Simian Immunodeficiency Virus SIVmne in Protection against Homologous Cloned and Uncloned Virus Challenge in Macaques.
- P. S. Polacino, V. Stallard, J. E. Klaniecki, S. Pennathur, D. C. Montefiori, A. J. Langlois, B. A. Richardson, W. R. Morton, R. E. Benveniste, and S.-L. Hu (1999)
J. Virol.
73, 8201-8215
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- Potent and Stable Attenuation of Live-HIV-1 by Gain of a Proteolysis-resistant Inhibitor of NF-kappa B (Ikappa B-alpha S32/36A) and the Implications for Vaccine Development.
- I. Quinto, M. Mallardo, F. Baldassarre, G. Scala, G. Englund, and K.-T. Jeang (1999)
J. Biol. Chem.
274, 17567-17572
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- Immunologic and Virologic Status after 14 to 18 Years of Infection with an Attenuated Strain of HIV-1 -- A Report from the Sydney Blood Bank Cohort.
- J. C. Learmont, A. F. Geczy, J. Mills, L. J. Ashton, C. H. Raynes-Greenow, R. J. Garsia, W. B. Dyer, L. McIntyre, R. B. Oelrichs, D. I. Rhodes, et al. (1999)
N. Engl. J. Med.
340, 1715-1722
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- Secretion of beta-chemokines by bronchoalveolar lavage cells during primary infection of macaques inoculated with attenuated nef-deleted or pathogenic simian immunodeficiency virus strain mac251.
- P Caufour, R Le Grand, A Cheret, O Neildez, F Theodoro, B Boson, B Vaslin, and D Dormont (1999)
J. Gen. Virol.
80, 767-776
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- Enhanced T-Cell Immunogenicity and Protective Efficacy of a Human Immunodeficiency Virus Type 1 Vaccine Regimen Consisting of Consecutive Priming with DNA and Boosting with Recombinant Fowlpox Virus.
- S. J. Kent, A. Zhao, S. J. Best, J. D. Chandler, D. B. Boyle, and I. A. Ramshaw (1998)
J. Virol.
72, 10180-10188
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- A Pathogenic Threshold of Virus Load Defined in Simian Immunodeficiency Virus- or Simian-Human Immunodeficiency Virus-Infected Macaques.
- P. Ten Haaft, B. Verstrepen, K. Uberla, B. Rosenwirth, and J. Heeney (1998)
J. Virol.
72, 10281-10285
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