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Science 3 October 1997:
Vol. 278. no. 5335, pp. 78 - 79
DOI: 10.1126/science.278.5335.78
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Perspectives

RNA SYNTHESIS:
MutT Prevents Leakiness

Bryn A. Bridges

Reading the genetic code into RNA and then protein is never 100% accurate, and cells have several proofreading and editing functions to correct for this. In his Perspective Bridges discusses the mechanisms used to cleanse the RNA and DNA precursor pools of nucleotides damaged by oxidation, including one requiring the MutT protein as reported by Taddei on p. 128 of this issue.

The author is at the Medical Research Council Cell Mutation Unit, University of Sussex, Falmer, Brighton BN1 9RR, UK. E-mail: b.a.bridges{at}sussex.ac.uk

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biochemical characterization of a novel hypoxanthine/xanthine dNTP pyrophosphatase from Methanococcus jannaschii.
J. H. Chung, J. H. Back, Y. I. Park, and Y. S. Han (2001)
Nucleic Acids Res. 29, 3099-3107
   Abstract »    Full Text »    PDF »
DNA Synthesis and Viability of a mutT Derivative of Escherichia coli WP2 under Conditions of Amino Acid Starvation and Relation to Stationary-Phase (Adaptive) Mutation.
B. A. Bridges and S. Ereira (1998)
J. Bacteriol. 180, 2906-2910
   Abstract »    Full Text »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)