Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 3 October 1997:
Vol. 278. no. 5335, p. 9
DOI: 10.1126/science.278.5335.9e
Prev | Table of Contents | Next

This Week in Science

Under the wrong circumstances, T cells can be turned off, instead of on, by the antigen for which they are specific. Boussiotis et al. (p. 124) found that the resultant state of unresponsiveness, called anergy, is maintained by the presence of an activated small G protein, Rap1. Thus, the inability to respond to antigen is not only due to a break in the signaling pathway that culminates in the production of the cytokine interleukin-2, but to the active turning on of an alternative pathway.

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)