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Science 17 October 1997:
Vol. 278. no. 5337, pp. 404 - 405
DOI: 10.1126/science.278.5337.404
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Perspectives

SOLID-STATE CHEMISTRY:
Crystal Gazing: Structure Prediction and Polymorphism

Gautam R. Desiraju

A given molecular structure can lead to more than one crystallized form, a phenomenon known as polymorphism. As discussed in the Perspective by Desiraju, polymorphism is an important scientific and technological question as more effort is brought to bear on the problem of designing materials. Moreover, polymorphism can have legal ramifications, as demonstrated in the litigation surrounding the ulcer drug Zantac.

The author is in the School of Chemistry, University of Hyderabad, Hyderabad 500 046, India. E-mail: grdch{at}uohyd.ernet.in

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Global Optimization of Clusters, Crystals, and Biomolecules.
D. J. Wales and H. A. Scheraga (1999)
Science 285, 1368-1372
   Abstract »    Full Text »
Strength of the Calpha H{middle dot}{middle dot}O Hydrogen Bond of Amino Acid Residues.
S. Scheiner, T. Kar, and Y. Gu (2001)
J. Biol. Chem. 276, 9832-9837
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)