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Science 24 October 1997:
Vol. 278. no. 5338, p. 573
DOI: 10.1126/science.278.5338.573
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Research News

NEUROBIOLOGY:
Enzyme Linked to Alcohol Sensitivity in Mice

Elizabeth Pennisi

Mice lacking a functional gene for an enzyme called Fyn tyrosine kinase are providing new insights into how alcohol affects brain neurons, and hints of why some people are more susceptible to alcohol addiction than others. Researchers report on page 698 that animals without the kinase stay drunk longer than normal mice, apparently because the enzyme normally counteracts alcohol's depressive effects on neurons, causing acute tolerance. When it is missing, the neurons--and thus the animals--fail to recover.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)