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Science 24 October 1997:
Vol. 278. no. 5338, pp. 575 - 576
DOI: 10.1126/science.278.5338.575b
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Research News

EVOLUTION:
Antibiotic Resistance: Road of No Return

Virginia Morell

ARNHEM, THE NETHERLANDS--They are one of medicine's biggest headaches: bacteria that have evolved resistance to those former wonder drugs, antibiotics. A random survey last year of Escherichia coli bacteria collected from a day-care center in Atlanta has indicated that these troublesome microbes will remain resistant long after doctors stop prescribing the drugs. Experiments suggest the reason: a second mutation that blocks the resistant bacteria from reverting to sensitivity.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)