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Science 7 November 1997:
Vol. 278. no. 5340, p. 1037
DOI: 10.1126/science.278.5340.1037
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News

CANCER RESEARCH:
Treatment Marks Cancer Cells for Death

Marcia Barinaga

Tumor-suppressor genes are an obvious target for cancer treatment, because they are lost or inactivated in many cancers. Most efforts to exploit these genes have taken a straightforward approach: trying to replace them or mimic their function with some other molecule (see main text). But one candidate cancer treatment tries instead to turn the absence of a tumor suppressor--the p53 gene--into an advantage.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)