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Science 21 November 1997:
Vol. 278. no. 5342, p. 1377
DOI: 10.1126/science.278.5342.1377p

This Week in Science

Of the several molecular mechanisms by which proteins get sorted and targeted to their specific destinations within a cell, two have been known to be conserved from bacteria to plants, but a third had been thought to be a new feature developed with the evolution of higher plants. Settles et al., with the cloning of the gene encoding the maize mutation hcf106, now show that this third pathway also is found in bacteria. Perhaps the substrates transported have changed, but the proteins that make up the machinery of the transport system find related genes among open reading frames of unknown function from several fully sequenced bacterial genomes. Investigation of the specific functions of those bacterial proteins may yield further surprises. [See the cover.]





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Science. ISSN 0036-8075 (print), 1095-9203 (online)