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Science 28 November 1997: Vol. 278. no. 5343, pp. 1578 - 1579 DOI: 10.1126/science.278.5343.1578
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Perspectives
Also see the archival list of Enhanced Perspectives
SIGNAL TRANSDUCTION:
Enhanced: A New Player in Cell Death
Timothy Hoey
Some small signaling molecules, the cytokines, convey their information to the nucleus of cells via proteins called STATs, using the ability of the STATs to phosphorylate and dimerize. In his Perspective, Hoey discusses a new way STATs can send their signals through the cell--through their COOH-terminal tails--that does not require phosphorylation or dimerization. These new results are reported in this issue by Kumar et al.
The author is at Tularik, South San Francisco, CA 94080, USA. E-mail: hoey{at}tularik.com
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Fas- and Interferon {gamma}-Induced Apoptosis in Chang Conjunctival Cells: Further Investigations.
- M. D. S. Jean, C. Debbasch, M. Rahmani, F. Brignole, G. Feldmann, J.-M. Warnet, and C. Baudouin (2000)
Invest. Ophthalmol. Vis. Sci.
41, 2531-2543
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- Interferon-{gamma} Induces Apoptosis and Expression of Inflammation-Related Proteins in Chang Conjunctival Cells.
- M. D. S. Jean, F. Brignole, G. Feldmann, A. Goguel, and C. Baudouin (1999)
Invest. Ophthalmol. Vis. Sci.
40, 2199-2212
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- Interleukin-6-induced Tethering of STAT3 to the LAP/C/EBPbeta Promoter Suggests a New Mechanism of Transcriptional Regulation by STAT3.
- M. Niehof, K. Streetz, T. Rakemann, S. C. Bischoff, M. P. Manns, F. Horn, and C. Trautwein (2001)
J. Biol. Chem.
276, 9016-9027
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- Enhanced Antiviral and Antiproliferative Properties of a STAT1 Mutant Unable to Interact with the Protein Kinase PKR.
- A. H.-T. Wong, J. E. Durbin, S. Li, T. E. Dever, T. Decker, and A. E. Koromilas (2001)
J. Biol. Chem.
276, 13727-13737
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