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Science 5 December 1997:
Vol. 278. no. 5344, pp. 1728 - 1729
DOI: 10.1126/science.278.5344.1728
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Perspectives
CELL BIOLOGY:
The Ins and Outs of Protein Translocation
Howard Riezman
Cells are tiny manufacturing plants for proteins. To ensure the quality of these products, the cell picks out misfolded and misassembled proteins and destroys them. In his Perspective, Riezman describes recent progress in understanding this quality control process and explains a report presented in this issue by Biederer et al., which sheds light on how these defective proteins are labeled for destruction by the cell.
The author is at the Biozentrum of the University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland. E-mail: riezman{at}ubaclu.unibas.ch
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