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Science 5 December 1997:
Vol. 278. no. 5344, pp. 1731 - 1732
DOI: 10.1126/science.278.5344.1731b
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Perspectives

Life in the Balance: Cell Walls and Antibiotic Resistance

Christine Jacobs

In her winning essay for the Pharmacia Biotech & Science Prize for Young Scientists, Jacobs describes her work on the control of cell wall synthesis in bacteria. Her results shed light on how one class of antibiotics (b-lactam antibiotics) kills bacteria and paves the way for the development of new antibacterial drugs.

The author is in the Department of Developmental Biology, Stanford University, Stanford, CA 94305-5427, USA. E-mail: jacobs{at}cmgm.stanford.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Role of Penicillin-Binding Proteins in the Initiation of the AmpC beta -Lactamase Expression in Enterobacter cloacae.
D. Pfeifle, E. Janas, and B. Wiedemann (2000)
Antimicrob. Agents Chemother. 44, 169-172
   Abstract »    Full Text »
Alzheimer's amyloid beta and lipid metabolism: a missing link?.
A. R. Koudinov, T. T. Berezov, and N. V. Koudinova (1998)
FASEB J 12, 1097-1099
   Full Text »
Characterization of a beta -N-acetylglucosaminidase of Escherichia coli and Elucidation of Its Role in Muropeptide Recycling and beta -Lactamase Induction.
W. Votsch and M. F. Templin (2000)
J. Biol. Chem. 275, 39032-39038
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)