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Science 12 December 1997:
Vol. 278. no. 5345, pp. 1898 - 1899
DOI: 10.1126/science.278.5345.1898
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Perspectives

Also see the archival list of Enhanced Perspectives

SIGNAL TRANSDUCTION:
Enhanced: Pieces of the True Grail: A G Protein Finds Its Target

Henry R. Bourne

One of the first to be discovered and still one of the most important, cyclic AMP is a second messenger inside cells, carrying information from outside signals to change processes inside. As described by Bourne in his Perspective and reported by Tesmer et al. and Sunahara et al., adenylyl cyclase, the enzyme that catalyzes this process, has now been crystallized with the molecule that turns it on, the G protein Ga, yielding a first glimpse into the molecular details that underly this critical biochemical reaction.

The author is at the University of California Medical Center, San Francisco, CA 94143, USA. E-mail: h_bourne{at}quickmail.ucsf.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dopamine-D2S Receptor Inhibition of Calcium Influx, Adenylyl Cyclase, and Mitogen-Activated Protein Kinase in Pituitary Cells: Distinct G{alpha} and G{beta}{gamma} Requirements.
B. Banihashemi and P. R. Albert (2002)
Mol. Endocrinol. 16, 2393-2404
   Abstract »    Full Text »    PDF »
Overexpression of the Heterotrimeric G-Protein {{alpha}}-Subunit Enhances Phytochrome-Mediated Inhibition of Hypocotyl Elongation in Arabidopsis.
H. Okamoto, M. Matsui, and X. W. Deng (2001)
PLANT CELL 13, 1639-1652
   Abstract »    Full Text »    PDF »
Gsalpha Repression of Adipogenesis via Syk.
H.-y. Wang and C. C. Malbon (1999)
J. Biol. Chem. 274, 32159-32166
   Abstract »    Full Text »    PDF »
gamma -Phosphate Protonation and pH-dependent Unfolding of the Ras{middle dot}GTP{middle dot}Mg2+ Complex. A VIBRATIONAL SPECTROSCOPY STUDY.
H. Cheng, S. Sukal, R. Callender, and T. S. Leyh (2001)
J. Biol. Chem. 276, 9931-9935
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)