TRANSCRIPTION:  Getting Around the Nucleosomes

doi:10.1126/science.278.5345.1899

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Science 12 December 1997:
Vol. 278. no. 5345, pp. 1899 - 1901
DOI: 10.1126/science.278.5345.1899

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Perspectives

TRANSCRIPTION:
Getting Around the Nucleosomes

Jonathan Widom

Inside cells, DNA, the genetic material, is wound around tiny spools of protein called nucleosomes. This efficient packaging method can makes DNA inaccessible for enzymes that make new DNA or proteins that regulate genes. In his Perspective, Widom explains how the cell solves this problem and what we learn from new experiments, presented in this issue by Studitsky et al., that illuminate the workings of one very big eukaryotic polymerase, polymerase III.

The author is in the Department of Biochemistry, Molecular Biology, and Cell Biology, and Department of Chemistry, Northwestern University, Evanston, IL 60208-3500, USA. E-mail: j-widom{at}nwu.edu

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