Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 16 October 1998:
Vol. 282. no. 5388, p. 377
DOI: 10.1126/science.282.5388.377l
Prev | Table of Contents | Next

This Week in Science

To start an immune response, dendritic cells pick up antigen and travel with it to the lymph nodes, where they come in contact with lymphocytes. Where, then, do the dendritic cells come from? Monocytes cultured in vitro with certain cytokines can differentiate into dendritic cells in about 1 week. Randolph et al. (p. 480; see the Perspective by Shortman and Maraskovsky) found that monocytes cultured for 2 days with a monolayer of endothelial cells and particles for phagocytosis will beget a population of dendritic cells that reemerge from beneath the monolayer. Thus, the source of dendritic cells may be blood monocytes that are exposed to particulate stimuli in the subendothelial milieu.




ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)