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Science 23 October 1998:
Vol. 282. no. 5389, p. 589
DOI: 10.1126/science.282.5389.589n
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This Week in Science

Three million people die each year of tuberculosis (TB), an infectious disease caused by certain strains of mycobacteria. In the host cell, these bacteria replicate in special intracellular compartments called phagosomes and are thought to escape destruction therein by secreting proteins that remodel the phagosomes. Berthet et al. (p. 759) show that a secreted mycobacterial protein called ERP (exported repetitive protein), which is found only in strains that cause TB and leprosy, is present in phagosomes and is essential for intracellular replication.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)