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Science 30 October 1998:
Vol. 282. no. 5390, p. 841
DOI: 10.1126/science.282.5390.841k

This Week in Science

Approximately 70 million people worldwide are chronically infected with hepatitis C virus (HCV), which can result in hepatitis, cirrhosis, and liver cancer. The inability to infect cells with HCV in vitro has made it difficult to study events in the virus life cycle that could provide clues to vaccines and therapeutic strategies. Pileri et al. (p. 938) have found that the viral envelope protein E2 binds to the major extracellular loop of the human protein CD81. Only chimpanzees who had been vaccinated with the viral envelope and resisted subsequent viral infection had antibodies that inhibited the ability of HCV to bind to CD81.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)