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Science 6 November 1998:
Vol. 282. no. 5391, p. 1005
DOI: 10.1126/science.282.5391.1005l

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Hollow micro- or nanoparticles have potential uses in areas such as drug delivery and catalysis. Synthesis methods include fabrication of a coated sphere followed by removal of the core by calcination or chemical dissolution. Caruso et al 1111 used a recently developed technique to make inorganic-polymer composite multilayer assemblies on colloidal particles. They subsequently removed the colloid to leave hollow spheres with multilayered shells. Submicrometer-sized hollow shells with wall thicknesses of tens to hundreds of nanometers were obtained. The method should allow the tuning of shell size, topology, and composition, as different shapes of the underlying colloidal particle could be used. The deposition technique for the layers should allow incorporation of a wide range of compounds, including biological macromolecules, dyes, or nanoparticles.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)