Related Content
Search Google Scholar for:
More Information
Related Jobs from ScienceCareers
|
|
Science 6 November 1998:
Vol. 282. no. 5391, pp. 1027 - 1030
DOI: 10.1126/science.282.5391.1027
|
|
News Focus
CANCER RESEARCH:
A Surprising Function for the PTEN Tumor Suppressor
Karen Hopkin
Cancer researchers believed that the protein product of the tumor suppressor gene PTEN, discovered last year, might suppress tumor cell growth by stripping off phosphate groups attached to tyrosine residues in other proteins. Now, a flurry of new work is showing that PTEN is a phosphatase, but its target is a fatty molecule, or lipid, that's tucked into the cell membrane--a completely new kind of target, as far as tumor suppressors are concerned. The target lipid is a key component of one of the cell's major growth control pathways; this knowledge could aid the development of treatments for cancers in which PTEN is mutated or in which this growth control pathway is overactive for other reasons.
Read the Full Text
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Regulation of Androgen Receptor Signaling by PTEN (Phosphatase and Tensin Homolog Deleted on Chromosome 10) Tumor Suppressor through Distinct Mechanisms in Prostate Cancer Cells.
- H.-K. Lin, Y.-C. Hu, D. K. Lee, and C. Chang (2004)
Mol. Endocrinol.
18, 2409-2423
| Abstract »
| Full Text »
| PDF »
- Extracellular Bad Fused to Toxin Transport Domains Induces Apoptosis.
- M. Ichinose, X.-H. Liu, N. Hagihara, and R. J. Youle (2002)
Cancer Res.
62, 1433-1438
| Abstract »
| Full Text »
| PDF »
- Single Mutations of the PTEN Gene in Recurrent Ovarian Carcinomas.
- T. Schondorf, A. Dostal, J. Grabmann, and U.-J. Gohring (2000)
Reproductive Sciences
7, 313-316
| Abstract »
| PDF »
- The Tumor Suppressor PTEN Negatively Regulates Insulin Signaling in 3T3-L1 Adipocytes.
- N. Nakashima, P. M. Sharma, T. Imamura, R. Bookstein, and J. M. Olefsky (2000)
J. Biol. Chem.
275, 12889-12895
| Abstract »
| Full Text »
| PDF »
- Overexpression of Kinase-Associated Phosphatase (KAP) in Breast and Prostate Cancer and Inhibition of the Transformed Phenotype by Antisense KAP Expression.
- S. W. Lee, C. L. Reimer, L. Fang, M. L. Iruela-Arispe, and S. A. Aaronson (2000)
Mol. Cell. Biol.
20, 1723-1732
| Abstract »
| Full Text »
- The Role of Phosphatases in Inositol Signaling Reactions.
- P. W. Majerus, M. V. Kisseleva, and F. A. Norris (1999)
J. Biol. Chem.
274, 10669-10672
| Full Text »
| PDF »
- Identification of Multiple Phosphoinositide-specific Phospholipases D as New Regulatory Enzymes for Phosphatidylinositol 3,4,5-Trisphosphate.
- T.-T. Ching, D.-S. Wang, A.-L. Hsu, P.-J. Lu, and C.-S. Chen (1999)
J. Biol. Chem.
274, 8611-8617
| Abstract »
| Full Text »
| PDF »
|
|
