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Science 6 November 1998:
Vol. 282. no. 5391, pp. 1059 - 1060
DOI: 10.1126/science.282.5391.1059
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Perspectives

ION CHANNELS:
Exciting Times for PIP2

Frances M. Ashcroft

One class of potassium channels, the KATP channels, are key players in a variety of functions-insulin secretion, blood vessel tone, and the response of the heart to lack of oxygen. Ashcroft describes in her Perspective how new results in this issue explain a long-standing puzzle about the true sensitivity of these channels to ATP. Baukrowitz et al. and Shyng et al. show that the phospholipid PIP2 regulates the ATP sensitivity of these channels.

The author is at the University Laboratory of Physiology, Oxford OX1 3PT, UK. E-mail: frances.ashcroft{at}physiol.ox.ac.uk

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Science. ISSN 0036-8075 (print), 1095-9203 (online)