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Science 13 November 1998:
Vol. 282. no. 5392, p. 1225
DOI: 10.1126/science.282.5392.1225n
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This Week in Science

How does the immune system learn to ignore its own antigens while responding quickly to antigens expressed by microbes or on grafts from nonidentical donors? Alferink et al. (p. 1338) show that the neonatal immune system has different trafficking patterns for lymphocytes than does the adult system. For a short period of time after birth, T cells have much greater access to the skin, for example. This trafficking depends on the selectin adhesion molecules that are expressed on the endothelium and allows the immune system to become tolerant to antigens found only in that location.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)