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Science 20 November 1998:
Vol. 282. no. 5393, p. 1381
DOI: 10.1126/science.282.5393.1381k
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Many studies of homeodomain proteins, which often function as transcription factors, have focused on their similarities across species. Ting et al. (p. 1501; see the Perspective by Nei and Zhang) have considered genes that have rapidly diverged. They identified a rapidly evolving homeobox gene in Drosophila at the Odysseus locus, which is responsible for reproductive isolation between sibling species of Drosophila. Although related genes are found from mammals through Drosophila, the gene shows a remarkable rate of divergence between species of Drosophila. Thus, both development and speciation may be dependent upon homeobox genes.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)