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Science 11 December 1998:
Vol. 282. no. 5396, p. 1953
DOI: 10.1126/science.282.5396.1953f
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The mechanism of infection by Mycobacterium leprae, the bacterium responsible for leprosy, and for a class of viruses known as arenaviruses have been unexpectedly linked to muscular dystrophy (see Perspective by Spear). Rambukkana et al. (p. 2076) showed that M. leprae uses a-dystroglycan--a protein of the dystrophin complex implicated in muscular dystrophy--to mediate its internalization by its target Schwann cells. Cao et al. (p. 2079) demonstrate that arenaviruses, including lassa fever virus, use the same protein as their host cell receptor.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)