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Science 11 December 1998:
Vol. 282. no. 5396, p. 1953
DOI: 10.1126/science.282.5396.1953h
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Recognition of lipopolysaccharide (LPS), a product of Gram-negative bacteria, can lead to toxic shock, but animals without a response to LPS cannot effectively clear Gram-negative infections. The protein responsible for transmitting signals from LPS to the cell has been found by Poltorak et al. (p. 2085). Two mouse strains known to be defective in their response to LPS had mutations in the toll-like receptor-4 (Tlr-4) gene--one strain had a mutation in the coding region and the other lacked transcripts from the gene entirely. Tlr-4 is thus necessary for LPS signaling in mice; the endogenous Tlr-2 gene, which in humans can transmit signals from LPS, does not replace Tlr-4 function in mice.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)