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This Week in ScienceA. Stasiak et al. comment that the authors' interpretation is unlikely and suggest instead that "the observed peaks preceding the final breakage could be the 'signatures' of progressive tightening of complex knots in the polysaccharide chain."In response, although H. Gaub et al. "agree that knotted polymers will break at lower forces than unentangled ones," they present a reanalysis of their data which indicates that only about 5% of the events they observed might reflect tightening of knots.The full text of these comments can be seen at www.sciencemag.org/cgi/content/full/286/5437/11a
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Science. ISSN 0036-8075 (print), 1095-9203 (online)