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Science 15 October 1999:
Vol. 286. no. 5439, pp. 447 - 450
DOI: 10.1126/science.286.5439.447
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News

Keeping Genome Databases Clean and Up to Date

Elizabeth Pennisi

As the size of GenBank, the public archive that contains every published DNA sequence, and the number of other biological databases grows, so does the need for ways to update and coordinate the information they contain. Genomics experts estimate that some 2% of GenBank's entries may contain DNA introduced by experimental procedures. In other entries, bases are missing or incorrect in stretches of supposedly finished sequence, or genes are even placed on the wrong chromosome. Dozens of teams of bioinformaticists and biologists are trying to tackle the problems, but it's a daunting task, and a lack of funds is hampering more systematic approaches to the problem, such as having experts review incoming information or developing ways to link existing entries with new data.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Current methods of gene prediction, their strengths and weaknesses.
C. Mathe, M.-F. Sagot, T. Schiex, and P. Rouze (2002)
Nucleic Acids Res. 30, 4103-4117
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Re-annotating the Mycoplasma pneumoniae genome sequence: adding value, function and reading frames.
T. Dandekar, M. Huynen, J. T. Regula, B. Ueberle, C. U. Zimmermann, M. A. Andrade, T. Doerks, L. Sanchez-Pulido, B. Snel, M. Suyama, et al. (2000)
Nucleic Acids Res. 28, 3278-3288
   Abstract »    Full Text »    PDF »
Can bioinformatics help trace the steps from gene mutation to disease?.
W. D. Graf (2000)
Neurology 55, 331-333
   Full Text »    PDF »
Powers and Pitfalls in Sequence Analysis: The 70% Hurdle.
P. Bork (2000)
Genome Res. 10, 398-400
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Science. ISSN 0036-8075 (print), 1095-9203 (online)