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Science 29 October 1999:
Vol. 286. no. 5441, pp. 913 - 914
DOI: 10.1126/science.286.5441.913
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Perspectives

CELL CYCLE:
New Tools for the Antimitotic Toolbox

Duane A. Compton

One of the drawbacks of the slew of anti-mitotic drugs that are used to treat cancer is that they all target the assembly or disassembly of tubulin, the molecular building block of microtubules. By disrupting the polymerization of tubulin into microtubules, which are the essential components of the mitotic spindle without which mitosis cannot proceed, these drugs are able to inhibit the cell cycle. In a Perspective, Duane Compton discusses a new screening method that identifies anti-mitotic drugs that target components of the spindle other than tubulin. These compounds should prove valuable both in elucidating the different steps in spindle assembly and as the basis of a new class of anticancer agents.

The author is in the Department of Biochemistry, Dartmouth Medical School, 7200 Vail Building, Room 413, Hanover, NH 03755-3844, USA. E-mail: duane.a.compton{at}dartmouth.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
High-Throughput Bioluminescence Screening of Ubiquitin-Proteasome Pathway Inhibitors from Chemical and Natural Sources.
F. Ausseil, A. Samson, Y. Aussagues, I. Vandenberghe, L. Creancier, I. Pouny, A. Kruczynski, G. Massiot, and C. Bailly (2007)
J Biomol Screen 12, 106-116
   Abstract »    PDF »
2-Methoxyestradiol, an Endogenous Estradiol Metabolite, Differentially Inhibits Granulosa and Endothelial Cell Mitosis: A Potential Follicular Antiangiogenic Regulator.
W. Shang, I. Konidari, and D. W. Schomberg (2001)
Biol Reprod 65, 622-627
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)