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Science 12 November 1999:
Vol. 286. no. 5443, p. 1253
DOI: 10.1126/science.286.5443.1253o
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The p44 mitogen-activated protein kinase (MAPK) and its isoform, p42 MAPK, participate in signaling in response to many different stimuli in a broad range of cell types, and it has not been clear whether each has specific functions or whether the two enzymes can compensate for one another. Pagès et al. (p. 1374) describe the phenotype of mice lacking the p44 mitogen-activated protein kinase. Mice lacking p44 MAPK were viable and fertile, but had specific defects in maturation and proliferation of thymocytes. Although p44 MAPK is not an essential protein for life (probably because the remaining p42 MAPK prevents complete loss of function), it appears to have a distinct biological role in the development of the immune system.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)