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Science 26 November 1999:
Vol. 286. no. 5445, p. 1645
DOI: 10.1126/science.286.5445.1645h
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This Week in Science

Rheumatoid arthritis is an autoimmune disease in which both T cells and B cells become activated. Most current research has centered upon finding specific antigens of the joint that could be the immunogenic targets for T cell-mediated damage. In a mouse model of arthritis that seems to mimic many of the features of the human condition, Matsumoto et al. (p. 1732) have determined that the antigen with the arthritogenic activity for the B cells as well as the T cells is from the same protein, glucose-6-phosphate isomerase, a ubiquitously expressed enzyme. Thus, local autoimmunity need not be caused by a tissue-specific antigen.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)