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Science 3 December 1999:
Vol. 286. no. 5446, p. 1813
DOI: 10.1126/science.286.5446.1813e
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This Week in Science

The value of the annual flu vaccine is directly related to how well it can be determined which flu strain will actually predominate in the seasonal onslaught. Bush et al. (p. 1921; see the Perspective by Hillis) have analyzed the molecular evolution of flu strains through recent years and arrived at a means to predict more accurately which strain will emerge in the next flu season. Their process, which involves identification of codons under positive selection to change, successfully predicted in retrospective tests the flu strains for the last 8 years.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)