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Science 3 December 1999:
Vol. 286. no. 5446, pp. 1866 - 1867
DOI: 10.1126/science.286.5446.1866
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Perspectives

Also see the archival list of Science's Compass: Enhanced Perspectives

EVOLUTIONARY BIOLOGY:
Enhanced: Predictive Evolution

David M. Hillis

Each year an international panel of virology experts must recommend which flu virus strains to include in the preparation of the vaccine to combat the upcoming flu season. As Hillis explains in his Perspective, this tough challenge should be made easier by the finding that those viral strains showing the greatest number of substitutions among amino acids in the HA1 domain of hemagglutinin (the spike-like protein on the viral surface that elicits an immune response) are more likely to contribute to future flu epidemics (Bush et al.).

The author is in the Section of Integrative Biology and Institute of Cellular and Molecular Biology, School of Biological Sciences, University of Texas, Austin, TX 78712, USA. E-mail: dhillis{at}mail.utexas.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)