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Science 10 December 1999:
Vol. 286. no. 5447, p. 2041
DOI: 10.1126/science.286.5447.2041m
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Proteasomes generate the appropriate peptides for display on major histocompatibility complex (MHC) class I proteins. The protein PA28 binds to proteasomes and increases their activity. Preckel et al. (p. 2162) made mice that were deficient in PA28b, one of the two subunits of PA28, and found that neither subunit was detected in these mice and that the types of peptides that bound to MHC class I had changed. The lack of PA28 seemed to affect the assembly of "immunoproteasomes," those protease complexes that contain the interferon-g-regulated subunits and that efficiently produce peptides that bind class I.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)