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Science 5 October 2001:
Vol. 294. no. 5540, pp. 66 - 67
DOI: 10.1126/science.1066237
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Perspectives

CELL CYCLE:
Order from Destruction

Jiri Bartek and Jiri Lukas

Cyclin E and its kinase partner CDK2 are essential for initiating duplication of the genome during S phase of the cell cycle. But how is cyclin E itself regulated? In a comprehensive Perspective, Bartek and Lukas describe new findings in this issue (Koepp et al.) and elsewhere that identify an F-box protein called Fbw7/hCdc4/Ago as the controller of cyclin E degradation. Intriguingly, mutations in this F-box protein are associated with some forms of breast and ovarian cancer.

The authors are at the Institute of Cancer Biology, Danish Cancer Society, DK-2100 Copenhagen, Denmark. E-mail: bartek{at}biobase.dk

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Science. ISSN 0036-8075 (print), 1095-9203 (online)