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Science 5 October 2001:
Vol. 294. no. 5540, p. 9
DOI: 10.1126/science.294.5540.9n
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Prions are the likely causative agents in new variant Creutzfeldt-Jakob disease (vCJD) and bovine spongiform encephalopathy (BSE), as well as scrapie. Experimental vaccination against prion disease in mice has been impaired by poor immunogenicity of the prion protein (PrPSc) resulting from partial immune tolerance to the endogenous host form of the protein, PrPc. Heppner et al. (p. 178) generated transgenic mice in which the clonal antibody repertoire was skewed toward prion recognition. Immunization of these animals with PrPSc resulted in protection from neuropathic changes associated with scrapie, even when genes for endogenous PrPc were reintroduced.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)