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Science 12 October 2001:
Vol. 294. no. 5541, p. 261
DOI: 10.1126/science.294.5541.261j
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Vancomycin is sometimes the only antibiotic available for combating infections caused by specific Gram-positive bacteria, and the rise of strains resistant to vancomycin is becoming a major public health concern. From an analysis of the effect of glycolipid derivatives of vancomycin on Escherichia coli, Eggert et al. (p. 361) have found that the mechanism by which these derivatives killed bacteria does not appear to be the same as that used by the parent compound. These results suggest possible modifications of vancomycin that might extend its utility.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)