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Science 12 October 2001:
Vol. 294. no. 5541, pp. 318 - 319
DOI: 10.1126/science.1066160
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Perspectives

SIGNAL TRANSDUCTION:
Calcium Channels--Link Locally, Act Globally

Stephen R. Ikeda

Ca2+-dependent gene transcription and L-type Ca2+ channel inactivation share a common initiating event. As Ikeda explains in his Perspective, in each case, local increases in [Ca2+] result in binding to calmodulin that is tethered to the Ca2+ channel protein. An accompanying conformational change triggers phosphorylation of the transcription factor CREB and closure, or inactivation, of L-type Ca2+ channels (Dolmetsch et al.).

The author is in the Laboratory of Molecular Physiology, Guthrie Research Institute, Sayre, PA 18840, USA. E-mail: sikeda{at}inet.guthrie.org

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Science. ISSN 0036-8075 (print), 1095-9203 (online)