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Science 19 October 2001:
Vol. 294. no. 5542, pp. 498 - 501
DOI: 10.1126/science.294.5542.498
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News Focus

BIOTERRORISM:
Vaccines for Biodefense: A System in Distress

Jon Cohen and Eliot Marshall

Two months before the 11 September terrorist attacks, an independent panel of experts concluded that the military's system for developing vaccines to protect troops from anthrax, smallpox, and other exotic bioweapons "is insufficient and will fail." The report, sources tell Science, may lead to a sweeping overhaul of how the federal government develops vaccines to protect both the military and civilians from bioweapons. But developing a new suite of vaccines presents difficult scientific challenges, and testing the safety and effectiveness of preparations against lethal diseases that aren't already widespread will be problematic.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Anthrax Vaccine and Public Health Policy.
M. M. Weiss, P. D. Weiss, and J. B. Weiss (2007)
Am J Public Health 97, 1945-1951
   Abstract »    Full Text »    PDF »
Flagellin Fusion Proteins as Adjuvants or Vaccines Induce Specific Immune Responses.
C. Cuadros, F. J. Lopez-Hernandez, A. L. Dominguez, M. McClelland, and J. Lustgarten (2004)
Infect. Immun. 72, 2810-2816
   Abstract »    Full Text »    PDF »
MtaR, a Regulator of Methionine Transport, Is Critical for Survival of Group B Streptococcus In Vivo.
D. Shelver, L. Rajagopal, T. O. Harris, and C. E. Rubens (2003)
J. Bacteriol. 185, 6592-6599
   Abstract »    Full Text »    PDF »
Anthrax as a Biological Weapon: An Old Disease That Poses a New Threat.
F. J. Tasota, R. A. Henker, and L. A. Hoffman (2002)
Crit. Care Nurse 22, 21-34
   Full Text »    PDF »
Effect of 5-Iodo-2'-Deoxyuridine on Vaccinia Virus (Orthopoxvirus) Infections in Mice.
J. Neyts, E. Verbeken, and E. De Clercq (2002)
Antimicrob. Agents Chemother. 46, 2842-2847
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)