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Science 26 October 2001:
Vol. 294. no. 5543, p. 741
DOI: 10.1126/science.294.5543.741l
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Different classes of pathogens infect and propagate themselves within their hosts by highly diverse means. Specialized dendritic cells (DCs) encode pathogen-specific molecular patterns and then direct the most appropriate immune response. Huang et al. (p. 870; see the Perspective by Modlin and Bloom) scrutinized genes expressed by DCs in response to viruses, bacteria, and fungi using microarray analysis. Along with a central cohort of genes that were expressed regardless of the pathogen encountered, large non-overlapping sets of genes were also induced, which suggests that highly tailored programs of expression occur.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)