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Science 26 October 2001:
Vol. 294. no. 5543, pp. 799 - 801
DOI: 10.1126/science.1066314
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Perspectives

IMMUNOLOGY:
Chip Shots--Will Functional Genomics Get Functional?

Robert L. Modlin and Barry R. Bloom

Dendritic cells are the frontline defense against invading microbial pathogens. But do they respond to a virus in the same way that they respond to a bacterium or a yeast? As Modlin and Bloom explain in their Perspective, gene expression profiling of human dendritic cells reveals that unique subsets of genes are activated in response to different pathogens (Huang et al.).

R. L. Modlin is in the Division of Dermatology and Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, CA 90095, USA. E-mail: rmodlin{at}mednet.ucla.edu B. R. Bloom is at the Harvard School of Public Health, Boston, MA 02115, USA. E-mail: barry_bloom{at}harvard.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)