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Science 9 November 2001:
Vol. 294. no. 5545, p. 1237
DOI: 10.1126/science.294.5545.1237n
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When mounting an immune response, antigens must be processed for presentation within the endocytic compartments of antigen-presenting cells, but antigenic proteins frequently contain disulfide bonds that might interfere with their breakdown and presentation. Maric et al. (p. 1361; see the Perspective by Watts) now show that the interferon g-inducible thiol reductase (GILT) found in late endosomes is important in the presentation of disulfide-bonded antigens. Knockout mice lacking GILT were less effective in processing and presenting disulfide-bonded antigens, including the model antigen hen egg lysozyme.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)