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Science 9 November 2001:
Vol. 294. no. 5545, pp. 1257 - 1258
DOI: 10.1126/science.294.5545.1257a
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News of the Week

PARKINSON'S DISEASE:
Dopamine May Sustain Toxic Protein

Jennifer Couzin

The symptoms of Parkinson's disease are rooted in the death of neurons that churn out the chemical messenger dopamine, but precisely what kills these brain cells has long stumped researchers. Now a provocative test tube study, reported on page 1346, suggests that a surprising culprit--dopamine itself--may assist in the neurodegeneration that defines the disease. Parkinson's researchers say the findings are intriguing and worthy of follow-up experiments but caution that they must be confirmed in cell cultures and laboratory animals.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)