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Science 23 November 2001:
Vol. 294. no. 5547, p. 1613
DOI: 10.1126/science.294.5547.1613o
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This Week in Science
In contrast to the situation with viruses, killed or inactivated intracellular bacteria make poor vaccines because they produce inadequate T cell memory compared with live bacteria. Lauvau et al. (p. 1735) studied the differences in CD8 T cell response induced by inoculation of mice with live versus dead preparations of the intracellular bacteria Listeria monocytogenes (LM). Although dead bacteria generated memory cells that could readily expand when confronted with live LM, these T cells could not protect mice against this infection. This deficiency correlated with the inability of CD8+ T cells from dead LM-immunized mice to produce interferon-g or generate cytotoxicity, the two main arms of the anti-LM response. Thus, important qualitative, rather than quantitative, differences may exist in immune priming by dead and live bacteria.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
