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Science 23 November 2001:
Vol. 294. no. 5547, p. 1640
DOI: 10.1126/science.294.5547.1640
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News Focus

GENE THERAPY:
Viral Vectors Still Pack Surprises

Eliot Marshall

Stripped of disease-causing elements, viruses work as natural syringes to inject DNA into human cells in gene therapy. Even so, researchers view their parasitic past with suspicion and worry about unforeseen problems in the clinic. The tamest viruses have produced surprises, as researchers using adeno-associated virus learned recently.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Recent developments in gene transfer: risk and ethics.
J. Kimmelman (2005)
BMJ 330, 79-82
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{alpha}5{beta}1 integrin as a cellular coreceptor for human parvovirus B19: requirement of functional activation of {beta}1 integrin for viral entry.
K. A. Weigel-Kelley, M. C. Yoder, and A. Srivastava (2003)
Blood 102, 3927-3933
   Abstract »    Full Text »    PDF »
Use of localised gene transfer to develop new treatment strategies for the salivary component of Sjogren's syndrome.
M R Kok, B J Baum, P P Tak, and S R Pillemer (2003)
Ann Rheum Dis 62, 1038-1046
   Abstract »    Full Text »    PDF »
Adeno-Associated Virus Type 2-Mediated Gene Transfer: Role of Cellular T-Cell Protein Tyrosine Phosphatase in Transgene Expression in Established Cell Lines In Vitro and Transgenic Mice In Vivo.
K. Qing, W. Li, L. Zhong, M. Tan, J. Hansen, K. A. Weigel-Kelley, L. Chen, M. C. Yoder, and A. Srivastava (2003)
J. Virol. 77, 2741-2746
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)