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Science 18 October 2002:
Vol. 298. no. 5593, pp. 621 - 622
DOI: 10.1126/science.298.5593.621
Prev | Table of Contents

Tech.Sight

PHAGE DISPLAY:
Affinity Selection from Biological Libraries

James F. Smothers, Steven Henikoff, Paul Carter

Phage display is a simple yet powerful technology that is used to rapidly characterize protein-protein interactions from amongst billions of candidates. This widely practiced technique is used to map antibody epitopes, create vaccines and to engineer peptides, antibodies and other proteins as both diagnostic tools and as human therapeutics. We overview the history of phage display and several recent applications.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)