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Science 22 November 2002:
Vol. 298. no. 5598, p. 1511
DOI: 10.1126/science.298.5598.1511l
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This Week in Science

Several cytokine receptors utilize the common cytokine receptor g chain (gc), and mutations in gc result in the condition known as X-linked severe combined immunodeficiency (XSCID). Lack of signaling through the interleukin-7 (IL-7) and IL-15 receptors leads to a loss of natural killer and T cells in XSCID patients, although the cause of the B cell defect is not established. Ozaki et al. (p. 1630) observed that B cells from mice lacking IL-21 receptor had altered antibody production. When combined with a loss of IL-4 signaling, a severely impaired immunoglobulin G response was observed that is strikingly similar to that seen in XSCID individuals.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)