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Science 29 November 2002:
Vol. 298. no. 5599, p. 1675
DOI: 10.1126/science.298.5599.1675m

This Week in Science

N-linked glycosylation is a common posttranslational modification of membrane and secretory proteins in eukaryotes. However, the only bacterium known to modify proteins in this way is Campylobacter jejuni, and thus many eukaryotic proteins generated in bacterial systems are of limited use because they lack appropriate modifications. Wacker et al. (p. 1790) have transplanted the N-linked glycosylation machinery from C. jejuni to Escherichia coli, which should enhance the opportunities for the large-scale production of appropriately modified proteins in bioreactors.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)