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Science 13 December 2002:
Vol. 298. no. 5601, p. 2087
DOI: 10.1126/science.298.5601.2087q
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This Week in Science
In addition to their well-defined role in antigen binding in the humoral immune response, antibodies recently have been shown to be capable of catalyzing the oxidation of water by singlet oxygen (1O2*). Wentworth et al. (p. 2195; see the Perspective by Nathan and the 15 November news story by Marx) confirmed that the hydrogen peroxide generated from this reaction can be produced at quantities sufficient for bactericidal activity. More surprising, however, was that another species from the reaction, which displays the tell-tale signs of ozone, was needed to finish the job; this same species was detected at the site of inflammation in an antibody-dependent in vivo model. Antibody-generated oxidants, including ozone, may thus be rudimentary contributors to immune defenses.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
