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Science 1 October 2004:
Vol. 306. no. 5693, pp. 67 - 68
DOI: 10.1126/science.1104611
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Perspectives

CELL BIOLOGY:
Chemical Genetics Hits "Reality"

David S. Bellows and Mike Tyers

Forward chemical genetic screening is analogous to the classical genetics strategy of mutagenesis, except that a small molecule takes the place of a genetic mutation in altering the function of one or more gene products. In their Perspective, Bellows and Tyers discuss an elegant forward chemical genetic screen that identifies small-molecule inhibitors called ubistatins that disrupt the cell's protein degradation machinery (Verma et al.). This work is an excellent example of the systematic identification of small-molecule inhibitors of complex biological processes and the characterization of their molecular targets.

The authors are at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. E-mail: tyers{at}mshri.on.ca

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Science. ISSN 0036-8075 (print), 1095-9203 (online)