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Science 28 October 2005:
Vol. 310. no. 5748, pp. 625 - 626
DOI: 10.1126/science.1115547
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Policy Forum

POLICY:
OPV Cessation--the Final Step To a "Polio-Free" World

R. Bruce Aylward,* Roland W. Sutter, David L. Heymann

The 20-year, U.S. $4 billion-dollar international effort to eradicate wild polioviruses now includes monovalent oral poliovirus type 1 vaccine (mOPV1), which was first given to 40 million children in India in April 2005. As this vaccine is being introduced to eliminate some of the last poliovirus reservoirs, the Global Polio Eradication Initiative is planning for the eventual synchronized worldwide cessation of the routine use of all oral poliovirus vaccines (OPVs) because of their capacity to cause, rarely, outbreaks of paralytic poliomyelitis. This Policy Forum reviews the feasibility and implications of eventually stopping the use of live polio vaccines.

The authors are with the Global Polio Eradication Initiative, World Health Organization, Geneva 27 Switzerland.

*Author for correspondence. E-mail: aylwardb{at}who.int

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Risks, Costs, and Benefits of Possible Future Global Policies for Managing Polioviruses.
K. M. Thompson, R. J. D. Tebbens, M. A. Pallansch, O. M. Kew, R. W. Sutter, R. B. Aylward, M. Watkins, H. E. Gary Jr, J. Alexander, H. Jafari, et al. (2008)
Am J Public Health 98, 1322-1330
   Abstract »    Full Text »    PDF »
Polio: an end in sight?.
T. Reynolds (2007)
BMJ 335, 852-854
   Full Text »    PDF »
Risk of Serious Neurologic Disease After Immunization of Young Children in Britain and Ireland.
K. N. Ward, N. J. Bryant, N. J. Andrews, J. S. Bowley, A. Ohrling, C. M. Verity, E. M. Ross, and E. Miller (2007)
Pediatrics 120, 314-321
   Abstract »    Full Text »    PDF »
Randomized, Placebo-Controlled Trial of Inactivated Poliovirus Vaccine in Cuba.
The Cuba IPV Study Collaborative Group (2007)
N. Engl. J. Med. 356, 1536-1544
   Abstract »    Full Text »    PDF »
An Antiviral Peptide Inhibitor That Is Active against Picornavirus 2A Proteinases but Not Cellular Caspases.
L. Deszcz, R. Cencic, C. Sousa, E. Kuechler, and T. Skern (2006)
J. Virol. 80, 9619-9627
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)