Frontiers in Neuroscience: The Science of Substance Abuse

Articles

Addiction Is a Brain Disease, and It Matters

Alan I. Leshner
Science 3 October 1997: 45-47.
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Interpreting Dutch Cannabis Policy: Reasoning by Analogy in the Legalization Debate

Robert MacCoun and Peter Reuter
Science 3 October 1997: 47-52.
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Drug Abuse: Hedonic Homeostatic Dysregulation

George F. Koob and Michel Le Moal
Science 3 October 1997: 52-58.
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Molecular and Cellular Basis of Addiction

Eric J. Nestler and George K. Aghajanian
Science 3 October 1997: 58-63.
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Psychoactive Drug Use in Evolutionary Perspective

Randolph M. Nesse and Kent C. Berridge
Science 3 October 1997: 63-66.
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A Range of Research-Based Pharmacotherapies for Addiction

Charles P. O'Brien
Science 3 October 1997: 66-70.
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This Week in Science

Editor summaries of this week's papers.
Science 3 October 1997: 9.
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Editorial:
The Science of Substance Abuse

Floyd E. Bloom
Science 3 October 1997: 15.
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 Science's Next Wave: Work in Clinical Research--Without a Medical Degree

Science 3 October 1997: 153.

News

AIDS/HIV:
Weakened SIV Vaccine Still Kills

Jon Cohen
Science 3 October 1997: 24-25.
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SYNCHROTRON RESEARCH:
Berkeley Facility Ranks Low on Advisory Panel's List

Andrew Lawler
Science 3 October 1997: 25-26.
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PROFESSIONAL SOCIETIES:
Furor Over Company Deal Roils AMA

Jocelyn Kaiser
Science 3 October 1997: 26.
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LABOR RELATIONS:
Stanford Researcher Fights Dismissal in Hospital Spat

Constance Holden
Science 3 October 1997: 27.
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OPEN MEETINGS LAW:
Government Bows Out of Academy Case

Andrew Lawler
Science 3 October 1997: 28.
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AUSTRALIA:
Scandal Claims Science Minister

Elizabeth Finkel
Science 3 October 1997: 28.
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NUCLEAR FUSION:
JET Takes a Step Closer to Break-Even

Alexander Hellemans
Science 3 October 1997: 29.
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U.K. ASTRONOMY:
Staff Makes Bid to Privatize Observatory

Nigel Williams
Science 3 October 1997: 29-30.
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CONGRESS AND THE BUDGET:
Friendly Finish Looms on Spending

Andrew Lawler
Science 3 October 1997: 30.
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FRANCE:
Socialists Reverse Budget Decline

Michael Balter
Science 3 October 1997: 31.
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MAD COW DISEASE:
New Studies Affirm BSE-Human Link

Nigel Williams
Science 3 October 1997: 31.
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MEETING BRIEFS:
Near the Lights of Vegas, Chemists Are on a Roll

Robert F. Service
Science 3 October 1997: 32-33.
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INDUSTRIAL CHEMISTRY:
Olefin Catalyst Keeps Things Short

Robert F. Service
Science 3 October 1997: 33-34.
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EVOLUTIONARY BIOLOGY:
Males Mutate More, Bird Study Shows

Steven Dickman
Science 3 October 1997: 34.
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ScienceScope

Science 3 October 1997: 23.
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Random Samples

Science 3 October 1997: 41.
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Special News Report

NEUROSCIENCE:
Getting the Brain's Attention

Ingrid Wickelgren
Science 3 October 1997: 35-37.
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NEURODEVELOPMENT:
Cocaine Wreaks Subtle Damage on Developing Brains

Gretchen Vogel
Science 3 October 1997: 38-39.
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Letters

"Science driven"

Science 3 October 1997: 17-20.
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 Top Talent at NSF

Mary Hanson
Science 3 October 1997: 17-20.
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 Ring Laser Design

H. R. Bilger
Science 3 October 1997: 17-20.
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 Analogies with Meaning

Robert Goldberg
Science 3 October 1997: 17-20.
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 NASA Funding for Earth Science

Robert Harriss
Science 3 October 1997: 17-20.
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 Polio Vaccine Production

Stanley A. Plotkin
Science 3 October 1997: 17-20.
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 Clean Air Skepticism

Frederick W. Lipfert
Science 3 October 1997: 17-20.
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 Genetic Evolution of Morphology

Stuart A. Newman
Science 3 October 1997: 17-20.
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 Resonance Raman Results: Retraction

Thomas G. Spiro
Science 3 October 1997: 17-20.
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 Corrections and Clarifications

Science 3 October 1997: 17-20.
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Books et al.

An Ongoing Debate

Wayne Hall
Science 3 October 1997: 75.
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Perspectives

METEORITICS:
Chondrites and the Solar Nebula

Adrian Brearley
Science 3 October 1997: 76-77.
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APPLIED PHYSICS:
Carbon Nanotubes for Next-Generation Electronics Devices

Susumu Saito
Science 3 October 1997: 77-78.
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RNA SYNTHESIS:
MutT Prevents Leakiness

Bryn A. Bridges
Science 3 October 1997: 78-79.
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 NEUROBIOLOGY:
Nota Bene: Unconscious Odors

Pamela J. Hines
Science 3 October 1997: 79.
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PROTEIN DESIGN:
Enhanced: Proteins from Scratch

William F. DeGrado
Science 3 October 1997: 80-81.
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 Webwatch

Science 3 October 1997: 81.
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Tech.Sight

 Tech.Sight: Products

Science 3 October 1997: 150-151.

Research Article

De Novo Protein Design: Fully Automated Sequence Selection

Bassil I. Dahiyat and Stephen L. Mayo
Science 3 October 1997: 82-87.
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Reports

Accretion Rates of Meteorites and Cosmic Dust in the Early Ordovician

Birger Schmitz, Bernhard Peucker-Ehrenbrink, Maurits Lindström, and Mario Tassinari
Science 3 October 1997: 88-90.
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Measurements of ¹²C/¹³C, ¹⁴N/¹⁵N, and ³²S/³⁴S Ratios in Comet Hale-Bopp (C/1995 O1)

David C. Jewitt, Henry E. Matthews, Tobias Owen, and Roland Meier
Science 3 October 1997: 90-93.
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Midwinter Start to Antarctic Ozone Depletion: Evidence from Observations and Models

H. K. Roscoe, A. E. Jones, and A. M. Lee
Science 3 October 1997: 93-96.
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Time-Domain Holographic Digital Memory

Xiao A. Shen, An-Dien Nguyen, John W. Perry, David L. Huestis, and Ravinder Kachru
Science 3 October 1997: 96-100.
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Nanotube Nanodevice

Philip G. Collins, A. Zettl, Hiroshi Bando, Andreas Thess, and R. E. Smalley
Science 3 October 1997: 100-102.
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Ste5 RING-H2 Domain: Role in Ste4-Promoted Oligomerization for Yeast Pheromone Signaling

Carla Inouye, Namrita Dhillon, and Jeremy Thorner
Science 3 October 1997: 103-106.
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Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing

Lisa K. Denzin, Derek B. Sant'Angelo, Craig Hammond, Michael J. Surman, and Peter Cresswell
Science 3 October 1997: 106-109.
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Interdomain Interactions Underlying Activation of Cyclic Nucleotide-Gated Channels

Michael D. Varnum and William N. Zagotta
Science 3 October 1997: 110-113.
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Mediation of Neuronal Apoptosis by Enhancement of Outward Potassium Current

Shan Ping Yu, Chen-Hsiung Yeh, Stefano L. Sensi, Byoung J. Gwag, Lorella M. T. Canzoniero, Z. Shadi Farhangrazi, Howard S. Ying, Min Tian, Laura L. Dugan, and Dennis W. Choi
Science 3 October 1997: 114-117.
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Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations

Yasuaki Tamura, Ping Peng, Kang Liu, Maria Daou, and Pramod K. Srivastava
Science 3 October 1997: 117-120.
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Rapid Colorectal Adenoma Formation Initiated by Conditional Targeting of the Apc Gene

Hiroyuki Shibata, Kaoru Toyama, Hisashi Shioya, Masaki Ito, Morihisa Hirota, Sumitaka Hasegawa, Hiroshi Matsumoto, Hiroshi Takano, Tetsu Akiyama, Kumao Toyoshima, Ryunosuke Kanamaru, Yumi Kanegae, Izumu Saito, Yusuke Nakamura, Kiyotaka Shiba, and Tetsuo Noda
Science 3 October 1997: 120-123.
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Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

Vassiliki A. Boussiotis, Gordon J. Freeman, Alla Berezovskaya, Dwayne L. Barber, and Lee M. Nadler
Science 3 October 1997: 124-128.
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Counteraction by MutT Protein of Transcriptional Errors Caused by Oxidative Damage

F. Taddei, H. Hayakawa, M.-F. Bouton, A.-M. Cirinesi, I. Matic, M. Sekiguchi, and M. Radman
Science 3 October 1997: 128-130.
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Functional Dynamics of GABAergic Inhibition in the Thalamus

Uhnoh Kim, Maria V. Sanchez-Vives, and David A. McCormick
Science 3 October 1997: 130-134.
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Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

Michael M. Ollmann, Brent D. Wilson, Ying-Kui Yang, Julie A. Kerns, Yanru Chen, Ira Gantz, and Gregory S. Barsh
Science 3 October 1997: 135-138.
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NF-AT Activation Induced by a CAML-Interacting Member of the Tumor Necrosis Factor Receptor Superfamily

Götz-Ulrich von Bülow and Richard J. Bram
Science 3 October 1997: 138-141.
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Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export

Batool Ossareh-Nazari, Françoise Bachelerie, and Catherine Dargemont
Science 3 October 1997: 141-144.
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Technical Comments

 The Possibility of Ice on the Moon

S. J. Weidenschilling;, S. Nozette, E. M. Shoemaker, P. Spudis, C. L. Lichtenberg;, N. J. S. Stacy, D. B. Campbell, and P. G. Ford;
Science 3 October 1997: 144-145.
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