Complex between a heterotrimeric guanosine triphosphate (GTP)-binding protein subunit (G_s) and the catalytic domains of its effector, adenylyl cyclase. G_s (light and dark gray; switch II helix in red) is activated by the nonhydrolyzable analog of GTP, GTPS. Forskolin is bound between the C1 (khaki) and C2 (purple) domains of adenylyl cyclase. The structure sheds light on the mechanism by which adenylyl cyclase is activated. See p. 1907, related Report (p. 1943), and Perspective (p. 1898). [Image: J. Tesmer and S. Sprang]

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